Monday, January 16, 2012


Anesthesia awareness

By susheel yeshala ,16th jan 2012,

Before going into details of anesthesia awareness let us have a look at following image which depicts the spectrum of consciousness. These cognitive activities have been reported during administration of drugs that are intended to induce and maintain general anesthesia.

Now getting in to the actual topic of anesthesia awareness,  we will begin with the working definition.

Definition: spontaneous postoperative recall of events occurring during  general anesthesia.
Anesthesia awareness includes both explicit memory and implicit memory. So what does these memories mean..
Explicit memory is information consciously recollected by the patient.
Implicit memory is information that is not associated with any conscious recollection.

Incidence: recent studies indicate that for every 1000 patients receiving general anesthesia 1 to 2 persons experience awareness due to anesthesia.

Risk assessment
    First of all, to understand the phenomenon of consciousness, or awareness during general anesthesia, it is first necessary to understand the types of drugs used during general anesthesia. Modern general anesthesia uses three separate categories of drugs to provide the triad of general anesthesia.
  • Sleep-inducing drugs. Separate drugs are used to keep people asleep and remove all memory of events occurring during the operation. Lower concentrations of these drugs in the blood also suppress breathing to some degree, and in larger concentrations they cause breathing to stop altogether.
  • Muscle paralyzing drugs. These drugs paralyze all the muscles of the body. They are necessary to prevent movements of body parts &spasm of muscles due to pain  during surgery. Hence paralyzed person cannot move, cannot speak, and cannot breathe(ventilator takes over the function of breathing). These muscle paralyzing drugs do not cause paralysis of heart muscles, bladder or bowel muscles, do not affect the functioning of the brain, which is why a person can be paralyzed by these drugs but fully  awake.
  • Analgesics.  Administered  to remove the pain of operations. These drugs administered at higher doses may cause the muscles of the body to become stiff, always cause people to feel calm.                                                                                                                        
There are several different experiences of awareness during anesthesia that are determined by the effects of the drug combinations. These different drug combinations explain all the horrific experiences, the partially conscious experiences, the fully conscious experiences, as well as the sometimes even wondrous conscious experiences of people under general anesthesia.
  • The person was awake, able to move, but felt no pain. These people have adequate concentrations of painkilling drugs in their body, but insufficient muscle paralyzing or sleep-inducing drugs in their bodies.

  • The person was awake, unable to move, but felt no pain. These people have adequate concentrations of painkilling and muscle paralyzing drugs in their bodies, but are awake because of insufficient concentrations of sleep-inducing drugs.

  • The person was awake, able to move, and felt the pain of the operation. These people have inadequate concentrations of all three groups of drugs in their bodies.

  • The person was awake, felt the pain of the operation, but was unable to move, speak, or do anything. This is due to inadequate concentrations of sleep-inducing and painkilling drugs, but where the person is still paralyzed by the muscle paralyzing drug. This is a disaster, a situation which all anesthesiologists dread having happen with their patients.
Anesthesia awareness is not always due to improper drug administration. Other possible causes are machine malfunction, use of cardiopulmonary bypass and finally errors in knowledge, judgement, vigilance, or technical expertise.

Anesthesia awareness is commonly feared by both anaesthesiologist and patients. For the later, possible adverse psychological sequelae include anxiety, sleep disorders, depression, nightmares, panic attacks, post traumatic stress disorder(PTSD), long term psychiatric disorders.

What does an anaesthesiologist do if he/she believes awareness due to anesthesia has occurred? First, there must be honest, sincere, and full disclosure of what happened. Second, patient should be reassured that repetition of awareness during a future anesthetic is not inevitable or even a likely occurrence. Third, it is essential to maintain  contact with patient through follow-up. Fourth, if necessary, referral for psychological conseling or psychiatric care should be given.

Direct monitoring of brain wave activity has been proposed as a method of preventing  anesthesia awareness. Considering this there is use of electroencephalogram(EEG), bispectral index monitor(BIS), patient state analyser(PSA).
                 Both BIS and PSA have a high probability of correctly predicting both loss and recovery of consciousness  with general anesthesia. The food and drug administration has approved both systems as clinical monitors for anesthetic effects of brain but the question is, can they be  used to prevent anesthesia awareness. They have their own advantages and disadvantages.
 Because is no monitor is universally accepted as having the ability to detect , monitor, and eliminate awareness, measures to prevent it becomes even more important. The following diagram shows possible interventions required to prevent anesthesia awareness.


Finally, because there is no good explanation for the mechanism of its development, it is not possible to identify patients at greater risk or to prevent all occurrences. Isolated incidents will likely continue, despite good practice and adherence to accepted monitoring standards.

Saturday, January 14, 2012

muscle relaxants

coming soon..

guys..! now i have to yell u that im working on an artical which most of us have myths, incomplete scientifically,less is known and alot to be known i.e. about ANESTHESIA AWARENESS...meanwhile there is no disruption to regular updates...